Selenium and Grave’s Disease/ Other supplements

This is not a new information in fact, but I am mentioning it here because there was just another scientific research about Thyroid eye disease and Selenium that I feel I should share with all of you..

Recently conducted study titled Selenium and the course of mild Graves’ orbitopathy” was conducted by the Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy. What happened: They  carried out a randomized, double-blind, placebo-controlled trial to determine the effect of selenium (an antioxidant agent) or pentoxifylline (an antiinflammatory agent) in 159 patients with mild Graves’ orbitopathy. The patients were given selenium (100 μg twice daily), pentoxifylline (600 mg twice daily), or placebo (twice daily) orally for 6 months and were then followed for 6 months after treatment was withdrawn. Primary outcomes at 6 months were evaluated by means of an overall ophthalmic assessment, conducted by an ophthalmologist who was unaware of the treatment assignments, and a Graves’ orbitopathy-specific quality-of-life questionnaire, completed by the patient. Secondary outcomes were evaluated with the use of a Clinical Activity Score and a diplopia score.

CONCLUSIONS made by the scientists: Selenium administration significantly improved quality of life, reduced ocular involvement, and slowed progression of the disease in patients with mild Graves’ orbitopathy.

Another older information about selenium as well:

On June 22, 2001 Dr. Barbara Gasnier reported the findings at the 83rd Annual Meeting of the Endocrine Society in Denver, Colorado that selenium supplementation may prevent progression of autoimmune thyroid disease, especially during the onset of the disease. According to the researchers, selenium deficiency appears to contribute to the development and maintenance of autoimmune thyroiditis because of its effect on the function of selenium-dependent enzymes, which can modulate the immune system.

Selenium supplementation with 200mcg of sodium selenite may improve the inflammatory activity seen in patients with autoimmune thyroiditis, but whether this effect is specific for autoimmune thyroiditis or may also be effective in other organ-specific autoimmune diseases remains to be investigated. Selenium supplementation may lower free radical activity, which contributes to inflammation.

It appears that taking selenium without iodine will result in a decrease in production of Thyroxine (T4), although there may be an initial transient increase in T4 to T3 conversion and hence higher T3 and seemingly worse hyperthyroidism.

Bottom line:  Selenium may be helpful for both- hyperthyroidism and thyroid eye disease (mild, but who knows). I know that almost any laboratory can measure if you need any vitamins and supplements. Better check that as well.

I also know that muscle cramps (I used to have a lot of these and they’ll wake me up during the night) are well administered by taking magnesium.

But again, I would just take vitamins and supplements on my own, check better with your family practitioner first.

Stay well,


5 responses to this post.

  1. Posted by trelokomeio on September 22, 2011 at 3:44 pm

    hello i have graves since 2008. for 2 years i wa as taking antithyr. drugs and finally got the levels to normal. then i stopped all pills and stayed like this for a year until last week when i checked my hormone levels and found that TSH was 0.05 again…
    the doctors opinion.. another round of antithyr. and then surgery since i have mild ofthalmopathy…
    since i dont want to have the surgery and since i feel that if i succeded in preventing normal levels of hormone for a year then it can happen i am searching alternatives…
    since i live in Greece there is no help in the alternative way of healing as “the doctor knows best~!!!”
    so how much selenium should do the work?
    i have already started a diet plenty of juises and fruits and nuts and no red meat sugar salt and all the others.
    any help would be extremely appreciated since you are my last hope of recovering and win this disease.
    thank you.
    by the way great work with this blog which is a big help!!
    sorry cannot affort to pay for the books…. thats why i search for anything that is free.


    • Posted by sbankova on September 22, 2011 at 5:32 pm

      Just a quick response, to the best I know: no nuts please, as they contain a lot of iodine..Stick with low iodine diet, a lot leafy vegetables etc., no stimulants like coffee, coke or anything that contains aspartame..
      As per Selenium- check the label for the recommended dose, usually it works.


  2. Posted by Frances on September 28, 2011 at 7:28 am

    wow this sounds interesting I love the more healthy options for this so will look forward to hearing more. Thank you for all you do


  3. Posted by Fidel Ramos on May 5, 2012 at 6:36 am

    Hi good day. I gone through surgery back in the Philippine in year 2007 and found out last October 2011 hyperthyroidism comes back when I felt my both of my eyes was irritated and water coming outside. Currently I’m taking medicine and as I observe of the last 2week my right eye started to bulg. Please advise any suggestion and remedies other than consulting a doctor every 2 months. I’m currently residing in UAE can anyone help me on this problem as far as I know I’m the only one having this kind of health problem in our family.

    Thanks in advance.

    Fidel M. Ramos


  4. I came to your site looking for help with my research on eye disorders and vision care for prevention. I found a lot of great into and I appreciate that. Thanks so much!


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